Jack Henion is Professor Emeritus of Toxicology at Cornell University in the Analytical Toxicology section of the diagnostic Laboratory at the College of Veterinary Medicine. He is also co-founder, Chief Scientific Officer, and Chairman of Advion BioSciences, Inc. located in Ithaca, New York.
Advion is a premier contract service laboratory specializing in LC/MS/MS analyses for the pharmaceutical and agrochemical industries. Dr. Henion’s work in LC/MS relates to the analysis of real-world samples common to pharmaceutical, environmental, and biochemical problems. He has published extensively in the areas of conventional capillary GC/MS as well as LC/MS, SFC/MS, IC/MS, and CE/MS using atmospheric pressure ionization (API) technologies with quadrupole, ion trap, and time-of-flight mass spectrometers.
For Dr. Henion’s CV, please Click Here.
The LC/MS courses listed below were filmed before live audiences presented by Dr. Henion. They have been developed in their entirety into an e-Learning format and are now available for delivery direct to your computer screen.
If you would like to view a few segments within each of our LC/MS courses, please click on the following link: LC/MS Guest Preview. When the registration page opens, enter your name and e-mail. Then, select the coures(s) you wish to preview. The index of topics for the respective course will open in your browser and you will be able to view the first two segments of each course to evaluate the content and presentation method.
To
purchase an LC/MS course by credit card for 1 to 15 people, click on the
‘Buy Now’ button below each course description. When
you submit your purchase, you will receive an e-mail with instructions for
enrolling individuals into the selected course(s). Once enrolled, students
will receive via e-mail, a link providing access to ALL lectures within
the course(s) that have been purchased.
Every few weeks thereafter, each student will receive (in sequence), links to the next lecture in the series. This spreads the content over several weeks and makes it easier for scientists and laboratory personnel to fit the learning into their busy schedules.
To order by invoice or for information regarding volume discounts, please contact Jim Henion, jghenion@cooplearningsol.com or call 607-279-4578.
PRACTICAL LC/MS: (An Introduction to API LC/MS Techniques)
INDEX OF TOPICS: Click here for a listing of the 38 segments covered.
COURSE DURATION: Approximately 12 hours.
SUBSCRIPTION PERIOD: 12 Months.
This course covers existing and new approaches to accomplishing on-line
LC/MS analyses. The course progresses from an introduction to HPLC and
mass spectrometry to themes common to all LC/MS interfaces, emphasizing
those phenomena that are important for success with LC/MS experiments.
Introductory lectures are followed by more advanced lectures on both
atmospheric pressure chemical ionization (APCI) and electrospray.
The content is presented along with representative applications for both
small and large molecules, including peptides, proteins, carbohydrates,
oligonucleotides, etc. Each lecture includes the "how-to"
aspects of each technique with the inclusion of many details and helpful
hints for carrying out successful experiments.
Also covered are qualitative approaches to LC/MS, quantitative analysis by LC/MS/MS techniques, the associated GLP aspects of such work, and a detailed overview of current strategies for biological sample preparation for LC/MS analyses. A final summary lecture highlights recent developments in LC/MS including new ionization techniques, mass analyzers, and chip-based devices with selected examples and insights toward the future.
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INDEX OF TOPICS: Click here for a listing of the 11 segments covered.
COURSE DURATION: Approximately 1.6 hours.
SUBSCRIPTION PERIOD: 6 Months.
This course is intended for those not associated with the technical aspects of drug discovery and LC/MS analysis. Those who will benefit from the LC/MS 101 course include people who work in administration, IT, QA, HR, accounting, sample receipt, manufacturing, engineering, sales, etc.
This is an introductory course that overviews why the pharmaceutical industry needs the information provided by LC/MS techniques and explains how LC/MS provides this information. The course provides an overview in non-technical terms how HPLC ('LC') works, followed by the basics of atmospheric pressure ionization (API) mass spectrometry.
We explain why coupling the formerly independent techniques of LC and MS provides a winning combination called LC/MS that has become widely accepted in the pharmaceutical industry. Representative examples of the data obtained are shown. A jelly-bean experiment is performed with audience participation to demonstrate the principles of precision and accuracy that are important for the quantitative determination of drugs and their metabolites. All material is presented in this course in a non technical way that is easy to understand.
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COURSE TUITION: $395
INDEX OF TOPICS: Click here
for a listing of the 45 segments covered.
COURSE DURATION: Approximately 8 hours plus Problem Solving.
SUBSCRIPTION PERIOD: 12 Months.
This
relatively advanced course covers concepts for interpreting the
collision-induced dissociation (CID) mass spectra of small molecules such
as drugs, drug metabolites, impurities, degradants, environmental
contaminants, etc.
The course is designed as a practical, comprehensive introduction, which
should enable the interested student to apply the basic rules of mass
spectral interpretation for determining the structure of unknown
compounds.
The prospective student should have a good understanding of organic
chemistry, reaction mechanisms, and the guidelines of physical organic
chemistry. It is desirable for the student to be familiar with the basics
of physical organic chemistry mechanisms, atmospheric pressure ionization
principles, tandem mass spectrometry and an understanding of EI mass
spectral interpretation.
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